Guided Mouse-ille is a 1967 Tom and Jerry cartoon, produced by Chuck Jones and directed by Abe Levitow. It was the second of three space-age Tom and Jerry shorts to be released in the Chuck Jones era, though taking a look at the MPAA code at the beginning of the cartoon would suggest that Guided Mouse-ille was the first of the three cartoons to be produced. According to episode number, It is the last Tom and Jerry cartoon to feature music by Eugene Poddany. However, O-Solar Meow could be the last specific cartoon according to the MPAA code to be produced. The cartoon was animated by Don Towsley, Tom Ray, Dick Thompson, Ben Washam, Ken Harris and Philip Roman, with music by Eugene Poddany and backgrounds by Thelma Witmer. The title is a pun of "Guided missile", which is a weapon. Chuck Jones had previously used a pun of guided missile for "Guided Muscle", a Warner Bros. cartoon in the Looney Tunes series featuring Wile E. Coyote and Road Runner.